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The degree of Polynesian and Caucasian admixture in the Norfolk pedigree has been previously estimated using the ancestry coefficient (Q) [24].
The BaPeq concentrations in Beijing have been previously estimated using a toxic equivalency factor (TEF) approach.
17, 18 Treatment adherence to antihypertensive drugs has been previously estimated using administrative databases from drug reimbursement programs.
SNP density in Clementine has been previously estimated using BACend sequences (BES) to be close to 1 SNP/Kb [ 31].
The rate equation derived from this scheme is: The kinetic parameters were fitted with the equation and are presented in table 1. Kinetic constants for the wild type enzyme have been previously estimated using the effects of a substrate analogue on substrate hydrolysis and on decarbamoylation [ 18].
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Each sample concentration was previously estimated using Qubit methodology (Invitrogen, USA).
All parameters were previously estimated using detailed data from the Two County Study (Tabar et al, 1992; Tan et al, 2006).
LA function was previously estimated using angiography [ 3], micromanometry [ 7, 8], and pulmonary pressure measurements [ 9, 10].
All model ML parameters were previously estimated using likelihood treescore from a preliminary BIONJ tree [ 39, 40].
Interval length in kb Proportion of SNP pairs having r with reversed sign within the interval Correlation of phase between two breeds (k and k') within the given interval Current effective population size of the breeds used in this study was previously estimated, using pedigree information, to be between 74 (Landrace) and 113 (Duroc, Yorkshire) [ 26].
The percentage of short repeats has been previously estimated at 5-105-10%9] using cot curves and at 18-22% [ 7, 8] using CsCl gradients for embryos of the Oregon R wild-type lab strain.
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