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This variant had been previously detected using a multiplex ligation-dependent probe amplification (MLPA) assay.
Note that oligomeric forms of WT α-syn have been previously detected using the yeast model (33).
These methods are able to reconstruct many gene regulations which have been previously detected using wet-lab experiments, for example, in Escherichia coli.
Also notable is the detection of ARS304 (MCM2-32), ARS319 (ORCMCM2-41) and ARS604 ORCMCM2-1055), three known ARSs that are inactive as chromosomal origins and have not been previously detected using array methodologies [ 24, 32- 37] 37].
None of these have been previously detected using either SAGE or microarray libraries from normal kidneys, (http://www.ncbi.nlm.nih.gov/geo/) [ 43, 75], suggesting that novel glomerular gene sets are induced as part of the pathophysiology of FSGS.
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These elements were previously detected using PCR approaches in 16 decapod species, including some shrimps, lobsters, crabs and galatheid crabs.
For the DPGP2 data set, common inversions were previously detected using the approach of Corbett-Detig et al. (2012).
Nearly half of the top FST signals (n = 22) were previously detected using a lower density SNP assay.
Here, we profiled the human whole exome methylation statuses of two samples and obtained the same patterns as were previously detected using WGBS [ 26].
Heteroplasmy, the existence of multiple mtDNA types within an individual, has been previously detected by using mostly indirect methods and focusing largely on just the hypervariable segments of the control region.
Provided that we filtered out cell-type-specific CpG sites from the list of age-modified CpGs and some of the age-modified CpG sites have been previously detected by using fractionated and unfractionated blood, it is less likely that compositional differences in cell counts may have affected these observations.
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