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Examples of introgression of such wild alleles into breeding programmes have been previously demonstrated including for increased drought and salinity tolerance which was achieved in tomatoes by introgression of genes from wild relatives.
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Athough fruit bats seropositive to EBOV and MARV have been detected elsewhere, antibodies to filoviruses have not been previously demonstrated in E. helvum, including E. helvum sympatric with R. aegyptiacus seropositive to EBOV and MARV [2], and long-term survival of seropositive bats has not previously been shown.
Furthermore, it has been previously demonstrated that epigenetic-targeted therapies, including inhibitors of histone deacetylases (HDACI), retain the ability to mediate cell death in the absence of a functional apoptosome via induction of autophagy.
Nonlinear control of an exothermic stirred-tank reactor has been previously demonstrated using a number of techniques, including nonlinear static state feedback and output feedback using observers.
TRAIL expression has been previously demonstrated in various liver-homing leukocytes, including Kupffer cells and NK cells and NKT cells.
A role for reduced leptin has been previously demonstrated in the adaptations to CR, including some of the post-restriction responses and weight regain (Rosenbaum et al., 2002; Rosenbaum et al., 2005).
Numerous risk CpGs were also annotated to genes that have been previously demonstrated to be linked to cervical cancer, including CALCA [ 38], CXCR4 [ 39], DCC [ 40], HOXC10 [ 10], MYOD1 [ 41], SFRP4 [ 42], SOX1 [ 43], TWIST1 [ 44] and WT1 [ 45].
This was particularly important with this population, since it has been previously demonstrated that most of the QTL detected, including those that affect abdominal fatness, a highly selected trait, were not fixed in the founder lines [ 10, 11].
The efficacy of ketorolac in decreasing postoperative pain following orthopedic surgical procedures including spine surgery has been previously demonstrated [ 12- 16].
The use of this array for cross-species hybridization with target samples from diverse Pinus species, including P. pinaster, has been previously demonstrated [ 7, 18].
It has been previously demonstrated that sst1 induces the activation of phosphotyrosine phosphatases, including the SH2-containing SHP-2 and PTPε.
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