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Among these 112 loci, only one (a component of a multidrug efflux pump mexD) has been previously annotated as an antibiotic resistance gene.
Three genes have not been previously annotated as being cell cycle regulated: FAM125B, ZNF646, ARHGAP11A.
These had not been previously annotated as AGOs (Additional file 1).
(2002), we considered only those transcription factors that had been previously annotated as involved in the ESR.
We used 52 families of ERVs in the human genome that had been previously annotated as primate-specific by RepeatMasker.
Genes copA and copB have been previously annotated as copper resistance related genes for many different xanthomonad genomes including Xoo, Xoc, Xcv, Xac and Xcc.
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In these assays, 815 bp corresponding to what was previously annotated as the xopD promoter region and the annotated XopD coding region (XopD216-760) were fused to the CyA sequence and detection of the CyA activity in pepper leaves reflected XopD translocation [43].
BA1544 from Bacillus anthracis was previously annotated as a transcription factor for the gene cluster ba1554 - ba1558, but has not been experimentally characterized.
These protein hits included 14 proteins that were previously annotated as ATP-binding proteins in the Saccharomyces Genome Database (SGD).
This can be illustrated by the case of three small RNAs that were previously annotated as miRNAs, which turned out to be members of the unusual class of ta-siRNAs.
Although the cobalamin transport genes were not identified in the genome of S. sp. PCC 7002 based on the annotation from RAST (Aziz et al. 2008) and Prokka (Seemann 2014), a recent study by Bryant and colleagues discovered the genes responsible for the cobalamin transport (btuBCF) in the cyanobacterium, which were previously annotated as siderophore uptake genes (Pérez et al. 2016a, b).
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