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The use of 5′UTR intron for enhancement of gene expression in this class of E3 ligases is likely an effective mechanism, as our analysis suggests it has been preserved in evolution.
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The higher degree of conservation both on the phosphoprotein and phosphorylation site level indicates that phosphorylation events occur on vital proteins within functionally important regions that are preserved in evolution.
That is, if a highly repressive MRE for fine-tuning the microRNA-mediated protein suppression provided a selection advantage, the highly repressive MRE would be preserved in evolution.
Also, theoretical studies suggest that functional compensation by duplicate genes can be preserved in evolution if it works for unexpected errors of gene function (e.g., null mutations; Nowak et al. 1997; Wagner 2000).
It could thus be inferred that the functions of the conserved miRNAs have been preserved in animals during evolution.
Among the differentially expressed miRNAs found, miR-1, miR-7 and miR-34 are highly conserved and mediate similar pathways, suggesting that some beneficial miRNAs have been preserved in animals during evolution.
Several have been preserved in both Australia and New Zealand.
A rarely used gene can be preserved in the genome during evolution as long as the null mutation rate is sufficiently low compared with the product of the probability that the gene is used at any given time and the fitness contribution of the gene when it is used.
How can redundant reactions be preserved in a metabolic network during evolution?
Additionally, the hydrophobicity profile and several characteristic motifs within gammaretroviruses are preserved in all full-length ENVV2s during evolution.
Determinism as unique evolution appears to be preserved in our mathematical models of chaos, which serve as our ontic descriptions of chaotic systems.[14] What would it take to raise questions about the determinism of actual-world systems?
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