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The overall structure of elongation complexes has been preserved during evolution, from bacteria to humans, suggesting that this allosteric control mechanism may a characteristic of transcription systems in general.
Remarkably, such primitive cell division mechanisms have been preserved during evolution even after centrioles were co-opted to take part of mitosis.
We have shown that this type of organization (REP- rayt-REP, Figure 1B) has been preserved during evolution and that both RAYTs and REPs undergo long-term coevolution.
Note that all the links in Fig. 5 have been preserved during evolution, suggesting the existence of a deeper reason why these domains seemingly always appear together in proteins.
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Yet, these sequences are preserved during evolution, probably due to repeat expansion processes [25].
Particularly, while the central domain is poorly conserved, the C-terminal domain contains two regions that are highly conserved from yeast to mammals, suggesting that such regions might be preserved during evolution to exert critical centromere functions (Figure 1) [23].
We have also shown that specific submodules contain more conserved domain groups and these are assumed to be preserved during evolution [ 87].
Briefly, the genes of the paleome form three sets, which differ in terms of the way their connectivity is preserved during evolution.
Although the biological function of MJ0927 remains unclear, this sequence analysis suggests that the hexameric spherical structure and its overall shape are preserved during evolution and thus may have functional significance.
Therefore, the two duplicate copies of foxi3 genes may have been preserved during vertebrate evolution by a sub-functionalization mechanism.
We argue that a tapered whisker provides some advantages for tactile perception (as compared to a hypothetical untapered whisker), and that this may explain why the taper has been preserved during the evolution of terrestrial mammals.
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