The transcriptional regulation of TERT is predominantly implicated in the regulation of telomerase activity in cells.
In contrast, GATA-4, -5 and -6 are predominantly implicated in heart and gut development (Laverriere et al, 1994; Molkentin, 2000).
Although ROS are predominantly implicated in causing cell damage and premature aging via oxidation of DNA, lipids, and proteins, they also play a major physiological role in several aspects of intracellular signaling and regulation, especially in cardiovascular tissues (Hare and Stamler, 2005; Kuster et al., 2010).
COX-2 has predominantly been implicated in modulating body temperature changes in response to infection.
This isoform has been predominantly detected in brain, heart and muscle tissues [ 79] and has been implicated as an oncogene in ovarian and breast tumors [ 80, 81].
MfdΔC, on the other hand, was predominantly monomeric in solution implicating the extreme C-terminal region in oligomerization of the protein.
Although the role of the p75NTR is highly debated, it predominantly binds the precursor pro-forms of neurotrophins and has been implicated in apoptosis [28].
ILC3 secrete predominantly IL-22 and IL-17 and have been implicated in the maintenance of intestinal barrier function and immune homeostasis [ 1].
It concomitantly revealed that they were predominantly twist positive, implicating these cells in the EMT process.
The oligomerization and aggregation of the amyloid-β (Aβ) peptide, a cleavage product of the amyloid precursor protein predominantly 40 or 42 amino acids in length, has been implicated in the pathogenesis of Alzheimer's disease.
