Surprisingly, we find that only 25% of compounds from the 'natural' odor library found in the top 500 predictions for each Or are predicted to activate multiple Ors.
However, An. gambiae lacks an ortholog for MAP3K1, an upstream activator for MEK/ERK signaling, so MAP4K4 activation of MAP3K7 (AgTAK1) would be predicted to activate NF-kappaB signaling through IKK (AGAP009166), and p38 MAPK and JNK signaling through MAP2K3 and MAP2K7 activation, respectively.
For the 485 regulators which are predicted to activate and repress, 224 have cocitations of their activation target list and 212 of their repression target list.
However, activation of the nif and isc operons is predicted to activate the cysE genes embedded in these operons resulting in the production of N-acetyl-L-serine that, in turn, will activate the cys operon via CysB helping to restore cysteine levels.
Several dopants are predicted to activate TiO2, resulting in a material optimal either for the oxygen evolution reaction, or for selective chlorine evolution.
Asp189 is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of configuration of either l- or d-substrates in contrast to d-only enzymes.
All of these effects would be predicted to activate SF-1 further [40], [41], [42], [43].
As one of the novel SNPs (IVS2-66A>C) was predicted to activate a cryptic 3' splice site near exon 3, a minigene splicing assay was used to determine if CTCFL undergoes SNP-dependent alternative splicing.
Loss of smLRP would thus be predicted to activate TGFβ/Smad signaling in VSCM by multiple independent mechanisms, and this is consistent with the dramatically increased nuclear pSmad2/3 levels in smLRP− aortas (Figure 1).
However the exact function of this miRNA on cell growth depends on the comprehensive effect of miR-181b regulated genes, and not on the number of miRNA regulated genes that are predicted to activate cell growth or inhibit cell death, so thus biological assays should be used to confirm the exact roles of miR-181b in Hela cells.
