Due to the relative small population sizes, it is predicted that human gene sequences are not strongly influenced by selection towards expression efficiency.
If such mechanisms do exist, it might be predicted that human treatment would promote an increase in the reproductive importance of the snail component of the life history, and therefore, that the force of transmission may not be reduced as much as expected by reference to reductions in the intensity and prevalence of human infections.
Population genetic data also indicate that some predicted 'loss-of-function' variants are also common in human populations: it has been predicted that a typical human is homozygous for approximately 20 such variants [ 25].
(3)– (6) It has been predicted that miRNAs could regulate approximately 60% of human genes, including many oncogenes and tumor suppressor genes.
It is predicted that the human complement of PPIs (the interactome) numbers between 130,000 and 600,000 [ 1, 2].
It is predicted that in humans, over 80% of genes are alternatively spliced [2].
Furthermore, if it turns out that the human JAK2V617F protein is fully functional in the mouse environment, then it would be predicted that mice expressing homozygous human JAK2V617F would produce a PV-like phenotype.
Using computational algorithms it was predicted that miRNAs regulate about 30% of human genes [4], but a recent inspection of human 3'UTR has shown that more than 60% of protein-coding genes maintain conserved target sites for miRNA recognition [5].
In humans, it is predicted that the colonizing bacteria would next progress to synthesis of the primary virulence factors CT and TCP, resulting in the onset of cholera disease, generally 1 5 days after exposure to the bacterium [21].
