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By power calculation, we should have been powered to observe a 30% decrease in amyloid plaque numbers and thus we conclude that reducing LRP1 levels does not produce a proportional decrease in amyloid plaque numbers.
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Many project evaluations are statistically underpowered to observe impact on nutritional status, but appear to be powered to observe impacts on food consumption and dietary quality, which we conclude are an appropriate level of impact of agriculture-nutrition projects.
The difference in walking between groups that this explanatory trial is powered to detect is smaller than that observed in a previous study with adult volunteers [ 14] (12.4 mins/day over the first week, Cohen's d = 0.90) due to participants being primary care patients rather than volunteers, there being lower anticipated fidelity of treatment delivery, and a longer duration of outcome follow up.
Lastly, as expected for a rare disease our case numbers are low and our study was powered to only observe a large effect size and unable to detect smaller differences in other lung function parameters.
Again our study was sufficiently powered to observe the differences described by Mahn et al. and therefore, the most plausible explanation is that decreased SERCA expression is not a consistent feature of ASM from subjects with asthma.
There was no evidence of a favourable change in sun-related attitudes or behaviour due to the intervention; although the study was insufficiently powered to observe other than large effects.
Second, the sample size was adequately powered to observe the desired effect.
As a feasibility study, this study was insufficiently powered to observe other than a large effect.
Our study was not powered to observe anything but marked haemodynamic effects, so we can only conclude that dexmedetomidine did not cause a dramatic increase in vasopressor requirement.
Additionally, the study was not sufficiently powered to observe significant differences in energy intake between the groups.
The study was powered only to observe a difference between pooled Rotarix™ group and placebo group.
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