Although uric acid (UA) can function as a systemic antioxidant, its pro-inflammatory properties have been postulated to play an important role in the pathogenesis of cancer.
Research suggests that adverse experiences in childhood affect the development of cardiovascular disease (CVD), and immune and inflammation dysregulation has been postulated to play role.
β-Amyloid (Aβ -induced toxicity Aβ -inducedve stoxicityve been postulandd toxidativeitical rolestresshaveathogenic mechanism of Alzheimer disease (AD).
Medial temporal lobe structures have long been postulated to play a role in autism and schizophrenia.
These epigenetic modifications have been postulated to play a role in senescence [13], [52].
Interaction between amyloid aggregates and the cell membrane has been postulated to play an important role in the neuropathology of Alzheimer's, Parkinson's and prion diseases [34].
mNSC ablation results in oxidative stress resistance [14], and DILP2 has been postulated to play a role in the response to oxidants [19].
Both pro- and anti-inflammatory cytokines have been postulated to play vital roles in development, rupture and repair of aneurysms [36], [37].
TGF-β has been postulated to play an important role in the maintenance of epithelial homeostasis and the development of epithelium-derived cancers.
Primary cilia have also been identified in the osteoblast lineage and have been postulated to play a role in osteoblast differentiation [8], [9].
VEGF has been postulated to play a role during inflammation and infections by increasing vascularity and promoting adhesion of leukocytes [26], [27].
