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Several modulating factors have been postulated to modulate cytosolic Ca2+ concentrations, e.g. magnesium [ 10], sympathetic activity [ 11], temperature [ 12], volatile anesthetics [ 13] or channel's redox state [ 14].
Diet, among other factors, has been postulated to modulate human capacity to produce LC-PUFAs from their essential C18 FA precursors, i.e. ALA and LA [16].
ClsA treatment led to increased expression of a rice ortholog of the Arabidopsis RADICAL-INDUCED CELL DEATH-1 gene which has been postulated to modulate methyl JA responses (Ahlfors et al. 2004).
PTBP1 has been postulated to modulate LDLR mRNA stability by binding to the 3' UTR [16], and therefore it is possible that such an interaction may also influence alternative splicing.
Both enzymes have been postulated to modulate inflammatory responses.
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A new wave of targets is now being pursued; many of these targets are postulated to modulate central pathways.
Apo E is postulated to modulate the astroglial response to damage, and to play a role in neuronal repair and re-innervation of the damaged circuitry [71].
In addition to the tumour suppressors and oncogenes discussed above, which have been shown to have an active role in autophagy regulation, several other tumour-associated factors could be postulated to modulate autophagy given their connection to pathways that have been previously implicated in autophagy regulation.
VDACs have also been postulated to regulate cell death mechanisms.
In addition, there are several brainstem areas, such as the raphe pallidus (RPa) and inferior olive (IO), two nuclei which have been functionally linked to the regulation of BAT thermogenesis (240, 243– 246), where VMH neurons have been postulated to relay to modulate SNS activity (2, 127, 241).
BRCA, XRCC3, DNA-PK [ 31] and CYCLIN B1 [ 32] levels have all been postulated to be important in modulating the effectiveness of a Chk1 inhibitor in combination with a DNA damaging agent.
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