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However, one limitation of scaffolds electrospun from natural proteins is the need to cross-link with glutaraldehyde for stability, which has been postulated to lead to many complications in vivo including graft failure.
Loss of endothelial HS has been postulated to lead to several pathological events, in particular to events related to atherosclerosis [ 13, 27].
Enhanced neurogenesis in such regions has been postulated to lead to increased neuronal density and function in this critical circuitry for new memory formation.
(29) The mechanism of semitargeted mutations is not well-understood, but misaligned template−primer structures with the correct nucleotide inserted opposite the damaged base have been postulated to lead to semitargeted mutations.
Interleukin-10 (IL-10); an anti-inflammatory cytokine is thought to inhibit proteolysis [ 18] while low levels have been postulated to lead to excessive inflammation and muscle damage [ 19].
In Europe, lack of sunshine and the consequent reduction of vitamin D synthesis in the skin has been postulated to lead to strong selection for LP (the calcium assimilation hypothesis).
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The interaction of the inhibitors with HLE is postulated to lead to the formation of a highly reactive N-sulfonyl imine (a Michael acceptor) that arises from an enzyme-induced sulfonamide fragmentation cascade.
β2-agonists with reduced tachyphylaxis are postulated to lead to improved tolerance profiles, thus therapeutically advantageous [7].
As such, for people with COPD, muscular deconditioning/dysfunction is postulated to lead to poor performance of ADLs and poor exercise tolerance.
Since mitochondria play a vital role in the primary mechanism of Ca2+ sequestration in a cell, its dysfunction is postulated to lead to pain hypersensitization [ 11].
This is postulated to lead to an isquemic environment where gas-producing micro-organisms reproduce, resulting in gas penetrating the wall of the gallbladder [ 2].
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