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To date, two focal adhesion proteins, talin and p130Cas, have been postulated to act as putative mechanosensors, acting through mechano-induced unfolding of their particular soft domain(s) susceptible to phosphorylation.
Dominant missense mutations in LRRK2 have been postulated to act via a toxic gain of function mechanism coupled with an increase in kinase activity7,8.
In addition to the Frizzleds, members of the LRP family (represented by the arrow gene in Drosophila) are also necessary for Wnt signal transduction and have been postulated to act as co-receptors.
However, in the past years, exercise has been postulated to act like a drug [2] and, as such, provides advantages and risks to an individual's health and fitness.
Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission.
The presence of multiple genes at sites of transcription (transcription factories) has been postulated to act as a stabilising force on chromosome architecture [39] and inhibition of transcription can cause some retraction of chromatin loops [40].
Similar(33)
Hence, NMD is postulated to act as a general quality control mechanism for defective or suboptimal splicing.
High-dose factor VIIa is postulated to act on platelets in the absence of tissue factor to activate factors IX and X and thus enhance thrombin generation.
The four other genes with a known function are: rubrerythrin, an iron-binding protein that is postulated to act as a ferroxidase for converting Fe(II) to Fe(III), hslU and hslV which together form a protease complex, and dimethylglycine dehydrogenase – an enzyme that is necessary for converting betaine to glycine.
Animal feeding experiments and in vitro studies [27], [28] have shown increased fibre digestibility following supplementation with a subtilisin-like protease feed additive, which was postulated to act by hydrolyzing cell wall structural proteins or protein-polysaccharide crosslinks and allowing better access for fibrolytic microbes [28].
Thus, DSBs are postulated to act as a downstream trigger of OMeG-induced apoptosis.
More suggestions(16)
been reported to act
been urged to act
been employed to act
been considered to act
been allowed to act
been adapted to act
been shown to act
been moved to act
been demonstrated to act
been volunteered to act
been proposed to act
been forced to act
been expected to act
been persuaded to act
been designed to act
been motivated to act
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com