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It has also been postulated that production of T-regulatory cells is impaired in HIV-infected subjects during HAART and might lead to decreased ability to suppress autoimmunity [20], [36].
It is clear that alloantibodies produced by B cells can cause (hyper)acute graft rejection and it has been postulated that production of donor specific alloantibodies after transplantation may be an important cause of late graft loss (1, 2).
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In addition to the ATP-depletion hypothesis, it has been postulated that increased production of nitric oxide (NO) also contributes to MPTP-induced neurotoxicity [ 11– 15].
It has been postulated that, in plants, production of 1-aminocyclopropane-1-carboxylic acid (ACC) by ACC SYNTHASE (ACS) is the rate-limiting step in ethylene biosynthesis (Argueso et al. 2007).
It has been postulated that delayed antibody production and accumulation of autoantibodies leads to complement activation through C1q, which triggers the enzymatic cascade of the classic complement activation pathway and recruitment of microglia and macrophages to the site of injury [ 111].
Together with the regulatory role of the physical chemical properties of the recirculating bile acid pool, 30 it has been postulated that opposing changes of cholesterol production and degradation might increase biliary cholesterol saturation and predispose to stone formation, 14 even if this was not confirmed by enzyme activity analysis in the liver tissue.
Soluble Fas can also be produced by activated peripheral blood lymphocytes [ 19] and it has been postulated that dysfunction of apoptotic pathways or production of soluble factors including sFas and soluble FasL may be involved in the pathogenesis of several autoimmune diseases [ 20] and in cancer [ 3, 4, 21].
It has been postulated that heavy weight might interfere with prolactin production [ 32].
It has been postulated that this increase might be due to an EPO-derived stimulation of cytokine production.
It has been postulated that osteoarthritic (OA) chondrocytes lose the ability to regulate their volume, affecting extracellular matrix production.
It has been postulated that under oxidant stress, Txnip dissociates from Trx1 and binds to NLRP3 to modulate the production of IL-1β through caspase-1 (61).
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