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Therefore, it has been postulated that peripheral BDNF is taken up by neurons of the central and peripheral nervous system.
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It has been postulated that palmitoylation of peripheral membrane proteins occurs exclusively in the Golgi apparatus, and that the responsible machinery lacks specificity altogether, rapidly processing any available target protein.
More recently, it has been postulated that in mammalian cells, the palmitoylation machinery for peripheral membrane proteins is devoid of specificity [29].
It has been postulated that FcγRIIb upregulation might constitute a critical checkpoint in peripheral tolerance by providing an inhibitory feedback that limits the ongoing humoral response to self-antigens.
High-dose statin therapy may be hepatotoxic and may cause peripheral neuropathy, and it has also been postulated that it can promote tumor growth, particularly in women [4] [7].
It has been postulated that the mechanisms responsible for the increased pericranial tenderness could be peripheral activation or sensitization of myofascial nociceptors.
It has been postulated that the changes of the conjunctival vasculature would better correlate with the peripheral vessels of the brain [ 10].
30 It has also been postulated that baldness is linked to CHD by mechanisms such as hyperinsulinaemia, chronic inflammation and increased peripheral sensitivity to androgens, and these are briefly discussed below.
It has been postulated that shock waves transmitted in an anterior-posterior direction, as in the case of a Nd Yag laser peripheral iridotomy, may induce a macular hole.
It has been postulated that 2-hydroxylated estradiol is anticarcinogenic.
It has been postulated that HIV infection is cleared from the brain after acute infection, and that CNS deficits occur because of re-entry of virus into the CNS during late-stage disease when there is high viral load in peripheral blood and immune impairment [4], [5].
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