It was postulated that alterations in mechanical properties of ECs are directly responsible for controlling the permeability of endothelium and for processes that occur during shear stress [ 14].
It has been postulated that expression profiles may partly be surrogates for microRNA alterations in sarcoma.
Since most patients survive the first days of sepsis, it has been postulated that acquired immune alterations may directly participate in a worse outcome through the inability to clear the initial infectious focus and/or decreased resistance to ICU-acquired infections.
It has long been postulated that ethanol-induced alterations in synaptic function underlie many of the drug's neuroadaptive effects that contribute to tolerance, physical dependence, and addiction (Lovinger and Roberto 2013 Vengelieneetet al. 2008; Zorumski et al. 2014).
It has been postulated that T-cell alteration occurs indirectly through other cells (Kerkvliet 2002), possibly during negative selection (Fisher et al. 2004) or by interaction with more TCDD-responsive cell types (Camacho et al. 2005; Kerkvliet 2002).
Given the apparently rapid and complete reversibility in most cases, it has been postulated that the mechanism is an alteration of renal hemodynamics.
Likewise it has been postulated "that tumor genomes are shaped by selection for alterations that promote survival and growth advantage, as well as by the particular dysfunctions in genes responsible for maintenance of genetic integrity" (Snijders et al., 2003).
It has been postulated that the features of arteriolar aneurysms and other retinal vascular alterations such as occlusion occur as a result of pathological changes triggered by an acquired inflammatory reaction [9].
It has been postulated that serotonergic neurotransmission has a significant function in nociception [ 17, 18]; alterations in 5-HT metabolism and transmission might therefore be important in the pathogenesis of FM.
It has been postulated that the mechanism of malformation and overgrowth during embryogenesis is due to the alteration of multiple signalling pathways including the insulin-like growth factor, vascular endothelial growth factor, and fibroblast growth factor pathways [ 84].
