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An active role for the immune system in controlling the malignant plasma cell clone in myeloma has been postulated for many years.
Since most melanomas metastasise to the lymph nodes, it has been postulated for many years that they spread through the lymphatic system (Elias et al, 1977).
However, dMYX blocks the propagation of DNA melting toward the active site, stabilizing a partially melted intermediate, the existence of which has been postulated for many years [ 22].
A pathogenic role for macrophages in pulmonary fibrosis has been postulated for many years, and described mechanisms have included overexpression of reactive oxygen species [ 147- 151], proteinase-activated receptors [ 152- 154], Fas ligand [ 155], and profibrotic cytokines [ 97, 154, 156- 162].
The existence of tissue-specific angiogenic factors has been postulated for many years [ 6– 9] but it only recently received confirmation when such a factor, named endocrine gland-derived vascular endothelial growth factor/prokineticin 1 (EG-VEGF/PROK1), was finally characterized [ 10].
The paradigm of a Th1 over Th2 dominancy in the early stages of MAP infection, that has been postulated for many years, is challenged by these data, which are further confirmed by the results of experimental MAP infections of sheep [ 25].
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The existence of this entity was postulated for many years until the first case was reported by Tubbs et al. [ 1] in 1982 followed by another report by Aucouturier et al. [ 2] in 1993.
Many methods have been postulated for predicting tonicity balance and the resulting change in plasma sodium (Na) changes.
Two different mechanisms have been postulated for their development.
Different reasons have been postulated for this effect.
A similar mechanism can also be postulated for the soldier sub-group - which has many internal connections.
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been known for many
been stifled for many
been criticized for many
been studied for many
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been conducted for many
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been snubbed for many
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