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In conclusion, many of the in vitro investigations carried out so far have been performed using high concentrations of glucosamine - concentrations that are unlikely to be achieved in plasma with oral doses of the drug.
Furthermore, most studies describing the biological effects of TGF-β have been performed using high concentrations of active, soluble TGF-β, despite the fact that TGF-β is produced and secreted as a latent complex.
Of note, however, is that a significant fraction of published microarray studies using the AR-dependent prostate cancer cell lines have been performed using high doses of androgen (≥10 nM) (Dehm and Tindall 2006), which induce profound cell cycle arrest in prostate cancer cells.
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In the past, high resolution computational simulations of viscous fingering instabilities have always been performed using high-order finite difference or Fourier-spectral methods which do not posses the flexibility to compute very complex subsurface geometries.
Recently, whole genome resequencing of rice cultivars using Nipponbare, as a reference have been performed using high-throughput sequencers.
The systematic characterization of the metabolic content of aqueous fecal extracts across humans, mice and rats has been performed using high-resolution NMR spectroscopy [ 60].
Previous canine genome-wide screenings for CNVs have been performed using high-resolution comparative genomic hybridisation arrays which have contributed with a detailed catalogue of CNVs.
Plant samples were extracted with methanol/water (1 1) and arsenic speciation was performed using high performance liquid chromatography coupled with atomic fluorescence spectrometry.
Detection of FB2 was performed using high performance liquid chromatography (HPLC) following the conditions recommended by Visconti et al. (2001).
Quantification of monosaccharides in the respective fermentation broths were performed using high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD).
CYN measurements were performed using High Performance Liquid Chromatography.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com