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Few investigations on global gene expression effects of α and β particle irradiation have been performed in normal (thyroid) tissue in vivo.
Regarding the other Nrf2 target genes, very few studies have been performed in normal human keratinocytes and contradictory results may be found in immortalized keratinocytes [28], [29].
Several pharmacokinetic studies have been performed in normal women.
Other studies have mostly been performed in normal populations of mares [ 26, 24], which may be one explanation of this difference.
While these studies have been performed in normal animals or within hours of the onset of inflammation, the situation during more chronic phases of inflammatory disease remains unclear.
Methylation profiling of the MUC5B distal promoter using bisulfite sequencing and pyrosequencing has also been performed in normal lung and in MUC5B-negative lung cancer tissues (Van Seuningen and Vincent 2009).
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Electrochemical tests, including potentiodynamic polarization curves and electrochemical impedance spectroscopy, were performed in normal saline physiological solution.
Blood sampling for AT plasma concentration was performed in normal rats and blood pressure-lowering effects were recorded continuously in hypertensive rats (HRs) before and at 1, 4, 8, 12, 16 and 24 h after drug administration.
The in vivo contrast effect was performed in normal, healthy New Zealand white rabbits weighing 3.0 kg.
To observe the in vivo MRI effect of lymph node, T2-weighted MRI was performed in normal healthy New Zealand White rabbits weighing 3.3 kg.
To accomplish this objective, biodistribution studies of 18F-7B were performed in normal FVB mice for preliminary assessment of signal-to-noise ratios and its clearance profiles.
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