This receptor saturation effect has been observed previously with somatostatin receptor-targeted peptides, both in preclinical biodistribution studies [9], as in clinical use [27],[28], and has also been observed even more prominently with bombesin analogues [29].
In concordance with what has been observed previously with docs1 1 plants, the docs1 2 line RRE was decreased of 86.5%, in comparison with a reduction of only 66.7% for the WT Nipponbare control roots.
This has been observed previously with the srgE gene of Salmonella, but only at the lower temperature of 30°C [20].
This has been observed previously with different combinations of parasites and mice [19], indicating that death in these strains is due to other causes, possibly related to the high parasitaemia levels.
This lack of fitness trade-off has been observed previously with VSV in vitro [22], [23], SLEV and WNV in vitro [29] and WNV in vivo [21], but stands in contrast to studies with the alphaviruses Sindbis virus, VEEV, and EEEV [16], [17] [19] and to recent in vitro studies with Dengue virus [20].
This variability has been observed previously with anti-Cnm67 antibodies using immunoEM (Adams and Kilmartin, 1999).
After 24 hours, it was found that the bioluminescent ratio increased dramatically, reaching levels that were significantly higher than what was observed previously with STS treatment (Figure 6a).
Such phenotypes were observed previously with a prsD mutant of R. l. bv.
Gel filtration analysis of the purified proteins suggested that UPPS Ec and UPPS Vv formed homodimers similar to what was observed previously with UPPS Bf and UPPS Ec.
The presence of an additional 42-kDa protein in the gel could be the result of a frameshifting event in the major capsid gene as was observed previously with coliphage T7 phage (Condron et al. 1991).
This phenotype has been observed previously, associated with disruption of genes involved in cell wall metabolism, such as the E. coli nlpD, encoding an M23 endopeptidase [ 61], and surA, encoding a peptidyl-prolyl isomerase [ 62].
