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In addition, loss of RIP3 expression has also been observed in primary colon cancer tissue, primary breast cancer tissue, most acute myeloid leukemia samples and chronic lymphocytic leukemia.12,13,14 These reports indicate that RIP3 deficiency could be associated with cancer development and progression.
It is worth noting, however, that we did not investigate the presence of gender homophily, which has been observed in primary schools [44], where the likelihood of infection transmission in school children of the same gender is high due to gender assortativity of contacts [41].
Mutations in components of the pathway have been observed in primary human cancers.
Altered expression of inflammatory molecules and angiogenic growth factors have been observed in primary pulmonary hypertension and/or non-sickle cell disease-related forms of secondary pulmonary hypertension.
Moreover, "loss of function" alterations of CEBPδ and promoter methylation of the C/EBPD locus have been observed in primary human breast tumors [26], [27].
Reduced efficacy of nelfinavir (NFV) has been observed in primary isolates from patients [ 10] and in vivo [ 11].
Similar(35)
A similar effect was observed in primary neurons treated with KPT-350 (Fig. 1e g).
An equivalent robust upregulation of HIF2α, but not of HIF1α, was observed in primary breast cancer cells (Fig. 1i, j).
Additionally, inhibition of TGFβ-stimulated phospho-SMAD was observed in primary human T cells.
However, no increase in surface expression of BST-2 was observed in primary monocytes or T cells treated with IL-6 (Fig. 2A and B).
A greater number of apoptotic cells were observed in primary and antral follicles in the HS group.
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