Sentence examples for been observed in preclinical from inspiring English sources
Musculoskeletal effects have been observed in preclinical studies with other MMP inhibitors [ 35].
Although virus dissemination has been observed in preclinical and clinical studies, its kinetics and pathways are still controversial.
The hypothesis that olaparib, by inhibiting DNA repair, will potentiate DNA damage induced by cytotoxics has been observed in preclinical combination studies.
It has also been observed in preclinical studies that incidence of thyroid C-cell tumors was increased in rodents treated with GLP-1 analogs (31).
Just as had been observed in preclinical studies, PRI-724 had a very acceptable toxicity profile, with only one DLT of grade 3 of reversible hyperbilirubinemia.
Chemopreventive and chemotherapeutic effects of these polyphenols have been observed in preclinical models of PCa, including both genetic and xenograft models [ 103– 105].
These limited trials attempt to measure in humans a specific biological effect of the agent, similar to what was observed in preclinical studies performed in animals.
Similar results were observed in preclinical studies in cynomolgus monkeys [ 15].
Similarly, development of the anti-CD40L mAb ABI793 was stopped after thromboembolisms were observed in preclinical studies in nonhuman primates.
27 A similar synergism was observed in preclinical models combining CTLA-4 blockade with xenogeneic DNA, rather than cellular vaccines.
Similar results were observed in preclinical studies using human dermal fibroblasts isolated from receptor-defective (n = 9) and receptor-negative (n = 4) HoFH patients exposed to alirocumab.
