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An enhanced ROS generation has been observed in inherited complex I deficiencies (Pitkanen and Robinson, 1996; Luo et al, 1997).
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Reduced UGT1A1 activity is associated with unconjugated hyperbilirubinemia and loss of function has been observed in rare inherited disorders (eg, Gilbert's syndrome and Crigler Najjar syndrome).
A deficiency of the syntrophin-dystrobrevin subcomplex has been observed in patients with inherited myopathy [11].
Mutations in the CD40L gene have been observed in cases of inherited hyper-IgM X-linked immunodeficiences [ 27].
Upregulation of LIF signaling has been observed in induced and inherited photoreceptor degeneration models [ 2, 13, 15, 16], as well as in models of ganglion cell death [ 17- 19].
The highest occurrence of methylation has been observed in GI cancers involving both sporadic and inherited types [ 58].
In agreement, a significant association between the inherited C150T mutation and longevity has been observed in both Finnish and Japanese populations [ 6].
This Y2K bug was inherited from the BSD ftp/ftpd programs and has been observed in unremediated Kerberos V5 systems.
Since mtDNA is inherited solely from the mother, it may be relevant that evidence for a maternal parent of origin effect has been observed in multiple sclerosis [3].
Extreme side effects of radiotherapy, including an increased cancer risk after radiation, were observed in patients with inherited disorders such as ataxia-telangiectasia and Nijmegen syndrome [ 16].
Inactivation of the pVHL tumour suppressor is observed in the majority of inherited and sporadic RCC leading to constitutive stabilization of both HIF-1 α and HIF-2 α and constitutive upregulation of HIF target gene expression (Kaelin, 2002).
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