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While similar observations have been observed in cell models of other polyglutamine diseases [24] [26], no impairment was observed in a polyglutamine-expanded ataxin-1 cell model using UFD or N-end rule UPS reporters [27].
Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between avalanche propagation and extinction.
Bistability has been observed in cell fate decision and differentiation in various cases [17], [18], [19].
Thus Rnd3 down-regulation of Syx would antagonize RhoA activation, as have been observed in cell culture [6], [35], [36].
High levels of DCC have been observed in cell body and terminal regions of developing and adult dopamine (DA) neurons [11] [12] [16] [16] [16] [16].
Aggregation of mitochondria has been observed in cell lines expressing MFN mutants [32], [33] and MFN2-deficient neurons and myotubes [34], [35].
Similar(33)
And similarly, there are about 10 to 20 other RNA-containing bodies, which have been observed in cells.
This apparent discrepancy has been observed in cell-based studies of the Ras GTPase, where both activation and inactivation of Ras have been observed in the presence of exogenously supplied RNS [44].
Recently, a novel type of wave dynamics, called inward rotating spiral waves, has been observed in cell-free yeast extracts [ 32].
No mechanism has been demonstrated to explain why peroxiredoxin oxidation states oscillate in such a wide range of nucleated and anucleated systems, nor has this oscillation been observed in cell-free preparations.
Indeed, evidence of arsenic-induced oxidative DNA damage has been observed in cell-based systems (Kojima et al. 2009; Pi et al. 2005) and in the biological samples of rodents and humans (Piao et al. 2005; Yamauchi et al. 2004).
More suggestions(19)
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