Sentence examples for been observed in aging from inspiring English sources

Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].

Degradation of the nuclear envelope has been observed in aging C. elegans previously [ 31].

28 Specifically, increased levels of interleukin (IL -1β, IL -1βand tumor necrosis factor-α (TNF-α) have been observed in aging rodent and human stumors.

Somatic changes to DNA methylation may also result from environmental exposures in adults, as have been observed in aging and disease processes such as cancer described in the next section.

In the case of SOD, conflicting results can be found in the literature because decrease [ 31, 55], no change [ 46], as well as increase [ 50, 56] in hepatic SOD activity have been observed in aging male Wistar rats.

It is noteworthy that similar pro-oxidizing shifts in thioredoxin and glutathione systems have also been observed in aging rodents (Cho et al., 2003; Rohrbach et al., 2006; Rebrin and Sohal, 2008), and might, at least in part, be explained by the observed decrease in cellular NADPH levels in aging rats (Parihar et al., 2008).

High doses of estrogen results in weight loss in rats, and an increase in tumor formation was observed in aging rats with long-term treatment of estrogen [14].

In agreement with this hypothesis, the activation of the checkpoint response is observed in aging tissues [ 5].

119 High plasma leptin levels are observed in aging rodent models 120, 121 as well as in humans 122, 123 suggesting that aging is a leptin-resistant state.

Second, the loss of SIRT1-driven transcriptional repression at its natural targets correlates with the deregulation of gene expression consistent with what is observed in aging tissues [ 45].

This rhythm was synchronized between subjects when measurements were corrected for individual differences in the sleep-wake-cycle, and a phase lag was observed in aging subjects and in eyes with early glaucoma [ 8, 14].