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Inconsistency has also been noted in randomized trials of the effects on glucose homeostasis.
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Clinical and histologic improvement after therapy have been noted in one randomized trial of bismuth subsalicylate and three randomized clinical trials of oral delayed-release budesonide.
Although a consistent association between glycemic control and cardiovascular disease has been noted in epidemiological studies (3– 5), randomized clinical trials (RCTs) did not show a benefit (6– 9).
β2 adrenergic agonists might also lead to lactic acidosis and cardiac arrhythmias, as were noted in another recent randomized controlled trial stopped early for potential harm [ 6].
For example, it is possible that simply having insurance coverage provided a sense of wellbeing and security that positively influenced answers to subjective questions in the absence of objective changes in health or access to care, as was noted in a recent randomized expansion of Medicaid in the state of Oregon in the US.
7 Although a preliminary anticancer effect was noted in metastatic CRPC, the clinical efficacy of cabozantinib cannot be accepted until the results of randomized trials are available.
Severe anemia was noted in 53 (51.5%) occasions.
Nevertheless, it must be noted that randomized controlled trials carried out in the pre-statin era clearly demonstrated that niacin was beneficial in preventing coronary events.
It should be noted that the randomized samples have the same mean with p-value = 0.9776.
(It should be noted that the reporting of hypoglycaemia in randomized controlled trials in the literature has not followed a consistent approach, and the definition of hypoglycaemia varies across trials 29, 30).
It should be noted that patients in the Internet intervention arm were not randomized but rather self-selected, thus potentially biasing the results.
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