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Interestingly, bilateral phasic responses were observed, which only partly overlapped with the tonic network and which would have been missed using a standard analysis.

Separating out these exposures allows the assessor to focus on combined exposures that would have been missed using a chemical-by chemical based approach.

Thus, most genes identified here would have been missed using a standard differential analysis of bulk gene expression.

The GSAO-induced Hic-5 mobility shift was found through this approach and would have been missed using a spot array or another technique not separating proteins by apparent molecular weight.

The asthma case definition that was used in this study contributed to better identification of children with asthma, who would otherwise have been missed using a history of audible wheeze alone.

Similar(55)

In this study one of the CT infections would be missed using a cut off score of 8.

Although common hexanucleotide indels at this locus are clinically benign, any pathogenic mutation present in cis would probably be missed using a conventional approach for variant detection.

However, because of the arbitrary multiple testing used in these studies, genetic variants that confer a small disease risk but are of potential biological importance are likely to be missed using a "most significant SNPs/genes" approach [ 9, 10].

However, it is also clear that higher E-value cutoffs (100 or above) are required to identify divergent homologues, since ~10% of homologues are missed using a cutoff of 1.

While the specificities of the stronger epitopes were described before (18, 27 – 29), responses to peptides 42, 151, and 164 would likely be missed using a vaccine delivery weaker than the CM regimen.

Also apart from supercoiling, the folded nucleoid also forms tertiary structures, which might form clustered regions which might be missed using a simple mapping of genes along the chromosome.

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