For this analysis, all the nsSNVs were mapped to functional sites that were obtained from UniProtKB sequence feature annotation.
Using the proteins identified from searching the S. oneidensis MR-1 spectra against the genomes of S. putrefaciens CN32, S. denitrificans OS217, and S. Typhimurium LT2, orthologs were mapped to functional categories to determine the level of conservation of protein function among the organisms.
The targets of these miRNAs were mapped to functional databases, including GO, KEGG, and MetaCore.
COGs annotations were mapped to functional linkages and the periplasmic location of all the proteins was predicted (see below).
Up- and downregulated genes in ccRCC were mapped to functional Gene Ontology (GO) categories using DAVID Bioinformatics Resources 6.7 [ 21].
Thus, the total number of evolutionarily conserved sites that were mapped to functional sub-families is 25, excluding the RRM domain, which does not have a detailed sub-family hierarchy in CDD at this time.
Both commonalities and differences underlying response effects can be extrapolated between species using transcriptomics and proteomics to identify genes and signaling pathways in one species that can then be mapped to functional pathways that are conserved across species (Bauer-Mehren et al. 2009).
Binding to the PP1 catalytic subunit has been mapped to the C-terminal functional core of the PPP1R15 family (Connor et al., 2001; Novoa et al., 2001) and is shared by the pared-down viral proteins (He et al., 1998).
The observed phenotypes have not been mapped to specific transcripts, and the potential functional involvement of these microRNAs remains unclear.
2) Reliable models can be built but the point mutation cannot be mapped to any functional sites.
