The known structure can be manipulated to include the sequence of an unknown protein and then, through simulation of forces on individual atoms of the unknown protein, to produce an approximation of the structure quite rapidly.
Aspects of mitochondrial function that have been manipulated to investigate this include: modulation of energy substrate utilization; activation of mitochondrial biogenesis; induction of mitochondrial antioxidant defenses and suppression of mitochondrial death programs including apoptosis and mitochondrial permeability transition.
Identification of these genes, whose expression is commonly regulated by the low fluid shear environment of spaceflight, provides key targets whose expression can be manipulated to control microbial responses, including potential use for development of vaccines and therapeutics.
The matrix components, matrix remodeling and matrix stiffness can be manipulated to perturb cellular behaviors, including survival, differentiation, migration and invasion.
Two design aspects that could be manipulated to increase peak flow mitigation include lengthening the flow path through the drainage layer to vertical gutters and use of flow-retarding drainage layer materials.
Studies included in our retrospective analysis were selected if they included a treatment where grazing was manipulated to control an IAP.
Those who think his administration should be deporting even more people claim that these numbers have been manipulated: the Department of Homeland Security now includes people sent back after a failed attempt to cross, which is fairly new.
Note that, according to Pereboom (2001, p. 121), his Four-Case Argument can be adjusted so that the details of how the agents in each of his first three cases are manipulated will include causes about how the agents come to view themselves subjectively and thereby take responsibility for their mechanisms of action.
The length of this period was determined by the clip with the latest auditory onset relative to the onset of natural mouth movements, thus ensuring that no clips were manipulated in order to include this 800 ms visual-only period.
It is not clear to what extent she may have been manipulated by other Palestinians, perhaps including her eldest brother, a leader of the Fatah faction of Yasir Arafat.
