This stress induced premature senescence (SIPS) [ 26, 27] has not been well documented in vivo, where it was mainly explored in cancer cells and in the tumour microenvironment [ 28].
While PTP1B and Grb-14 functions were mainly explored with regard to their causal role in T2DM and obesity, the prevalence of insulin resistance in conjunction with type 1 diabetes has recently gained attention [ 46, 47].
The resultant surfaces were mainly explored by STM and low-energy electron diffraction.
Due to the severe side effects of allo-HSCT, including high levels of treatment related mortality in the patients, this therapy option was up to now mainly explored in patients with refractory and far advanced solid tumors.
Also, the risk factors for mortality in older COPD patients have mainly been explored in patients who have been hospitalised for COPD [ 13, 14].
Recent theoretical developments in the field of cosmic ray research have been mainly in the direction of exploring non-linear aspects of the processes in which these particles are involved, namely the action of cosmic rays on the environment in which the transport and/or acceleration take place.
So far, sex-biased gene expression has mainly been explored in species with well-differentiated sex chromosomes, while species with young or undifferentiated sex-chromosome systems are just beginning to be studied [ 22– 22].
Clinical priority setting and bedside rationing by physicians have mainly been explored in studies from high-income settings.
