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Exact(25)
Although the catalytic function of the exosome core has been lost during evolution, the substrate recruitment and binding properties have been conserved from prokaryotes to eukaryotes.
So far, there is no report of an antivirulence gene of S. enterica that has been lost during evolution.
Therefore, it seems likely that the accompanying HERV16 and MLT2C2/MIB segment must have been lost during evolution.
Such facile extension/shrinking of the inborn secondary structure should not cause a disease; otherwise the species would have been lost during evolution [8].
For other organisms however, the expansion of this family originated from different members (data not shown), suggesting that NLRs of non-human origin have been lost during evolution.
The lack of this motif was also observed in other insects belonging to Diptera, suggesting that the second CXXC motif might have been lost during evolution (Fig. 2).
Similar(35)
In yeast, ERK presents a peptide in the C terminal tail, which is lost during evolution.
Nevertheless, it is noteworthy the preponderance of placental samples with preferential expression of maternal alleles, indicating that, although imprinted XCI was lost during evolution, a proliferative advantage may remain for cells that inactivate the Xp in human placenta.
Since the epigenetic marks of imprinted autosomes and of the imprinted Xi are similar in mouse placenta (reviewed in [38], [39]), one may envision that imprinted XCI in human extraembryonic tissues was lost during evolution in conjunction with autosomal imprinting.
According to the Savageau's demand principle [36], the mode of gene regulation should entail a maximization of the usage (binding to DNA) of the transcription factors; otherwise, the regulators are lost during evolution.
Underlined genes were lost during evolution.
More suggestions(15)
been selected during evolution
been lost during capacitation
been lost during preparation
been expanded during evolution
been sampled during evolution
been fixed during evolution
been lost during translation
been optimized during evolution
been lost during E-mail
been disrupted during evolution
been eliminated during evolution
been adapted during evolution
been observed during evolution
been maintained during evolution
been incorporated during evolution
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Justyna Jupowicz-Kozak
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