Within the neuron phospho-synapsin was localized to cellular projections but not in cell bodies, as expected.
ENT1, ENT2, and ENT4 are ubiquitously expressed in brain tissue and are localized to cellular membranes [ 138– 138].
Many up-regulated processes are localized to cellular component (endoplasmic reticulum) while down-regulated processes belong mainly to the cellular components (ribosome, extracellular matrix and cytoplasmic membrane-bound vesicle).
DOI: http://dx.doi.org/10.7554/eLife.02786.013 Analyzing the cells silenced for mDia1, we found that mDia1 was required for Ezrin-positive bleb formation as well as blebbing, while mDia1 was localized to cellular blebs in control silenced cells.
ATP13A2 protein has been localized to several cellular acidic vesicles, including lysosomes and autophagosomes (2– 10).
Using the existing Pathway Tools framework, we could indicate that different parts of a protein acting as an enzyme were localized to different cellular compartments by associating multiple Cellular Component Gene Ontology terms with the corresponding protein frame.
Lgl is localized to the cellular cortex, and functions in the same genetic pathway as dlg and scrib to maintain cellular polarity.
In addition, the enzymes controlling the metabolism of gycerolipids are localized to specific cellular compartments, while the lipids themselves are, for the most part, distributed to a much wider range of cellular compartments.
I therefore used WoLF-PSORT [40] to estimate the proportion of matched proteins that can be localized to various cellular compartments or that are extracellular.
In contrast, Gosert and coworkers reported that the MHV replication complex is localized to the cellular double membrane vesicles (DMVs); the RNA synthesis, replication and subgenomic mRNA transcription also take place in the cytoplasmic DMVs [21].
