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Constitutive over-expression of CTGF has been linked with systemic sclerosis, keloids and other fibrotic skin disorders [23] and the up-regulation of WISP1, a WNT signaling pathway target, has been associated with human idiopathic pulmonary fibrosis [24].
43 Alternatively, daytime napping could be the consequence of unnoticed nighttime sleep disturbance (eg, sleep apnoea) or sleep deprivation, which have been linked with systemic inflammation.
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The Hadza also had high levels of bacteria like Treponema, which is considered a sign of disease in Western populations because different types are linked with systemic lupus and periodontitis, as well as syphilis.
Our findings suggest that the preeclamptic state is linked with systemic inflammation and reduced numbers of Tregs.
Since the invention of the ophthalmoscope nearly 150 years ago and the first reports of retinal vascular changes (e.g., retinal arteriolar narrowing, venular widening, hemorrhages, microaneurysms) being linked with systemic diseases, numerous studies have advanced the concept that retinal measurements may predict a range of systemic diseases.
Loss of intestinal integrity has been linked with a systemic increase in expression of immunity-related genes [ 10].
The Eritrean government has been linked with "ruthless repression" and systemic human rights violations, including carrying out widespread detention and forcing citizens into indefinite military service, according to the UN's first inquiry into human rights in the secretive country.
Multiple forms of systemic immune suppression have been linked with an increased incidence of MCC 4. Indeed, patients with systemic immune suppression have a significantly worse prognosis 5 independent of stage.
Systemic inflammation has been linked with cancer development, cancer cachexia and poor outcome.
Recently, HIV-related microbial translocation that causes systemic activation has been linked with severity of HCV-related liver disease [ 42].
Systemic inflammation has been linked with adverse survival in a variety of cancer types (Falconer et al, 1995; Scott et al, 2002; Hefler et al, 2008).
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