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In brain, TNF- α is produced by microglia and its overproduction has been linked with neuronal cell death [ 49].
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Similar alterations appear to be linked with neuronal dysfunctions in the hypothalamic pituitary testicular axis and inadequate neurosecretory activities of pituitary cells (Lafuente et al. 2001).
Elevated glucocorticoids have been linked with outcomes such as impaired neuronal growth, modified immune function, and accelerated cellular aging.
Chronic stress has been linked with shrinkage of brain tissue (i.e., neuronal atrophy) and modulation of dendritic structure in the hippocampus (McEwen 2008; Watanabe et al. 1992) and was associated with reduced BDNF levels in that brain structure (Smith et al. 1995).
Loss of CaBPs has been linked with impaired Ca2+ homeostasis and is related with both neuronal and behavioral deficits [ 31].
Rabies has been linked with vampire folklore.
It has been linked with depression.
Although the mechanism of axon vs. dendrite formation has extensively been studied in 2D dissociated-cell cultures containing neurons isolated from in vivo tissues, whether the preceding or accompanying in vivo cellular events such as the birth and migration of neurons and their layer formation are linked with this neuronal polarization process and if so how is unknown.
Molecular pathways of NRSF target genes were linked with various neuronal functions in ESC, such as neuroactive ligand-receptor interaction, CREB signaling, and axonal guidance signaling, while they were not directed to neuron-specific functions in ESC-derived neurons.
Mounting evidence suggests that tinnitus can be linked with increased spontaneous neuronal activity [5], [6], [7], [8] leading to the use of drugs targeted at reducing spikes of increased activity.
Therefore, DYX1C1 might be linked with ERs and neuronal migration in causing dyslexia.
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