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RDW has been linked with inflammation in critically ill patients and with oxidative stress in animal models.
Poor sleep quality, impaired sleep [ 16, 17], and chronic psychological stress have also been linked with inflammation [ 18- 20].
Air pollution and particulate matter exposure have been linked with inflammation and inflammatory states have been linked with preterm delivery [ 32, 33].
Chronic psychological stress, in general, has been linked with inflammation [ 18], for instance through elevated levels of IL-6 and hs-CRP [ 19, 20].
64 To date, HAART has been linked with inflammation in the temporal cortex and the hippocampus, thus suggesting an association with working memory.
Premature birth is associated with a high rate of secondary morbidities, including acute and chronic lung disease, necrotizing enterocolitis, retinopathy, intraventricular hemorrhage, and intracranial white matter injury, virtually all of which have been linked with inflammation.
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Among these genes, COX-2, IFI-6 16 IFI-6 16were linked with inflandation, and CSTS2, COMP, CXCR4 and TXNIP were involinkedn matrix synthesis and cartilage destruction.
43 Alternatively, daytime napping could be the consequence of unnoticed nighttime sleep disturbance (eg, sleep apnoea) or sleep deprivation, which have been linked with systemic inflammation.
It suggests that pharmacologic manipulation of the ER stress pathway might be a novel treatment paradigm for particular GI diseases (such as IBD) and other disparate diseases (including cancer) that have been linked with chronic inflammation.
Although underlying mechanisms have not been completely explained, adipokines have been linked with obesity-induced inflammation and signaling pathways that contribute to type 2 diabetes (1).
The R92Q mutation has also been linked with other diseases associated with inflammation, such as rheumatoid arthritis and atherosclerosis [ 47- 49].
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