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Inflammation has been linked with endothelial dysfunction (Stenvinkel 2001).
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Furthermore Apovian et al. have recently demonstrated that local adipose tissue inflammation is linked with endothelial dysfunction [7].
As CD105 is a marker for activated endothelial cells, colligin 2 seems to be linked with endothelial activation and active angiogenesis.
Weight loss, with either diet [ 7, 8] and/or aerobic exercise [ 5] interventions, has previously been linked with increased endothelial function as measured by brachial FMD in overweight and obese women.
When measured in expert laboratories, brachial artery FMD has been linked with invasive coronary endothelial function testing and long-term cardiovascular risk.
Among these, tumor necrosis factor-α (TNFα) has been linked with reduced insulin sensitivity and decreased endothelial NO synthase expression in cultured endothelial cells [ 5], and interleukin −6 (IL-6) is implicated in endothelial dysfunction and vascular inflammation through several mechanisms, including induced expression of monocyte chemotactic protein-1 (MCP-1) [ 6].
It is also known that endothelial asymmetric dimethylarginine has been linked with elevated levels of homocysteine [35].
sFLT-1 has been linked with preeclampsia, a condition characterized by hypertension, proteinuria, and endothelial dysfunction [ 37].
Rabies has been linked with vampire folklore.
It has been linked with depression.
15 16 Fatty liver might play a part in the pathogenesis of CVD through the overexpression and systemic release of several inflammatory, haemostatic 17 and oxidative-stress mediators or via contributing to whole-body insulin resistance and atherogenic dyslipidaemia. 3 NAFLD has also been reported to be linked with circulatory endothelial dysfunction.
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