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Cellular senescence has also been linked with aging and age related pathology [ 3].
Muscle disease has been linked with aging as well as metabolic conditions, which prominently includes diabetes [ 1- 4].
This biochemical alteration has been linked with aging and more of 100 chronic-degenerative diseases, among which osteoporosis is found [ 1, 2].
Telomeres have been linked with aging and disease and, in the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Cancer has been linked with aging since genetic mutations accumulate with age and delayed aging has been associated with lesser incidence of cancers [ 9].
The dauer pathway (which also includes insulin pathway-like and guanyl cyclase pathway-like genes) is of high general interest, as it has been linked with aging [ 40], biodiversity [ 41] and the development of parasitism in nematodes [ 42].
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According to the mitochondrial theory of aging, mitochondria are among the key players contributing to the aging process, whose dysfunction is linked with aging [ 47] and age-related diseases [ 48, 49].
But the sir2 gene occurs in mice and humans, and Dr. Guarente believes it may be linked with aging in mammals through a different mechanism, one that involves its newly found chemical assistant.
92 It is well accepted that white matter hyperintensities (WMH) in imaging are linked with aging and AD.
Whether effects of excess UPR activity seen here in cultured chondrocytes contribute to OA in aging cartilage is a pertinent question, in part because decreased AMPKα activity is linked with aging in knee cartilage [ 19, 23].
Impaired cellular redox balance has been linked with age-related diseases, and neurodegenerative diseases, such as Alzheimer and Parkinson's disease [1].
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