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Given that the gene responsible for ADPKD has been linked with abnormalities of vascular smooth muscle, myofibroblasts, extracellular matrix and collagen defects [ 5], it seems reasonable for there to be widespread vascular abnormalities in this patient population, although it seems to be seldom described.
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At the level of brain physiology, schizophrenia is linked with abnormalities of brain connectivity.
This Treg defect is linked with abnormalities in the expression and function of CTLA-4.
Interestingly, Pla2g2a-Tg mice, which develop skin abnormalities [ 4], also show reduced plasma HDL levels [ 10], and disturbance of systemic lipid homoeostasis has often been linked with skin abnormalities in various mouse models and even in human diseases [ 33– 33].
Low back pain (LBP) has been linked with various abnormalities of the spine detectable on magnetic resonance imaging (MRI), including disc herniation, nerve root impingement, disc degeneration and high intensity zone (HIZ).
Hypergammaglobulinemia has been linked with the extent of histopathological salivary gland abnormalities and has been proposed as an activation marker in pSS [ 18, 19].
In order to reduce the burden of end-stage diabetic kidney disease, targeting glomerular hyperfiltration and hyperperfusion, early hemodynamic abnormalities that have been linked with greater risk of developing albuminuria and loss of renal function over time (2, 3), may be an attractive therapeutic option.
Abnormalities in PI signalling have been linked with gastrointestinal disorders; however, the mechanisms remained unclear.
Magnesium has been linked with a number of chronic diseases, including diabetes, hypertension and lipid abnormalities [ 29].
Rabies has been linked with vampire folklore.
It has been linked with depression.
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