A third example is atherosclerosis, as individuals at high risk of myocardial infarction have dozens of modulated eQTL effects [ 95], again in peripheral blood — although to date these have not been linked to variants that associate with myocardial infarction.
In that vein, he says, Representative Michael P. Forbes should not be sabotaging the center's offer to safely incinerate those 355 Vermont sheep that have been linked to a variant of mad-cow disease.
Mad cow disease, or bovine spongiform encephalopathy, is a fatal disease that affects the brains of cattle; it has been linked to a variant of Creutzfeldt-Jakob Disease, a fatal illness in humans.
Variable pain sensitivity in the general population has been linked to common variants of the μ-opioid receptor and of the catecholamine-O-methyltransferase genes potentially leading to increased opioid tonus.
Because constitutional epimutations in different tumor suppressor genes have been linked to sequence variants in the 5′ cis-regulatory region, - we sequenced a 3.4 kb upstream fragment including the BRCA1 promoter and exon 1.
Because constitutive hypermethylation in different tumor suppressor genes has been linked to sequence variants in the 5′ cis-regulatory regions (19, 21, 22), we sequenced a 3.2 kb upstream fragment including the BRCA1 promoter and exon 1 (Supplementary Material, Table S2).
However, its mere existence has been called into question as hypertensive kidney disease is diagnosed mainly in African Americans, and in this population CKD has been linked to a genetic variant in the ApoL1 gene that confers resistance to infection by Trypanosoma brucei [ 12, 13].
To date, no more than 20% of cases have been linked to structural genomic variants such as de novo CNVs and mutations, and monogenic syndromic disorders.
Beyond bacterial infections, a chronic human health risk that has been linked to animal feeding practices is variant Creutzfeldt-Jakob disease (vCJD), a novel human neuro-degenerative prion disease that is currently untreatable and fatal (Collinge 1999).
