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In some cases, inhibition of angiogenesis has been linked to suppression of angiogenic factor generation by cells neighbouring the vasculature [3]; [9].
As BMI1 expression has been linked to suppression of the Noxa gene [13], we analyzed naive CD4 T cells stimulated with delta-like 4 to determine if Noxa expression was altered.
For meropenem, the ratio of minimum concentration to MIC (Cmin/MIC) has been linked to suppression of resistance (16).
Induction of apoptosis by microtubule-targeted drugs has been linked to suppression of microtubule dynamics and prolonged mitotic arrest.
Various effectors from other nematode species have been linked to suppression of host defences and induction of the feeding site (Haegeman et al. 2012; Hewezi and Baum 2013).
NOTCH1 signalling has also been linked to suppression of HPV E6 and E7 protein expression in cervical carcinoma cell lines; expression of activated NOTCH1 causes growth inhibition of HPV-positive but not HPV-negative cervical carcinoma cell lines, and results in the downmodulation of HPV-driven transcription of the E6 and E7 viral genes.
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Consistently, in cells expressing vinculin-LD, a mutant lacking the interaction with acidic phospholipids, spreading and motility defects were observed, which were linked to suppression of lipid-mediated adhesion site dissolution [21].
If M2-induced cytotoxicity is linked to suppression of the immune response in M2-containing vaccines, then the incorporation of influenza M2 into a vaccination regimen should include the neutralization of its possible negative effects.
Symmetric di-methylation of histone H4 at arginine 3 (H4R3me2s) is linked to suppression of gene expression [ 36].
The premise that activation of EMT is linked to suppression of cellular senescence has been proposed also in the context of another EMT regulator, Zeb1 [ 52].
The upregulation of IFITM1 in cancer cells was associated with an increase in migration and invasive capacity, and its action in gastric tumour cells was linked to suppression of NK cells [ 12].
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