Both sites localised to surface exposed loop structures (Figure 3), and at both sites aa mutations associated with cluster transitions were found to also be linked to substantial variation in the molecular and electrostatic surface of the protein (Figure 5 and Figure 6).
Our experiment thus confirms that Bd infection was linked to substantial mortality in Alytes toadlets from populations where no mass mortality events caused by chytridiomycosis have been reported even though Bd is widespread ([27], U. Tobler and B. R. Schmidt, unpublished data).
Obviously, the modes differ in the objective flux which is linked to substantial differences in the other network fluxes.
Lymnaeidae exhibit a great diversity in shell morphology which is linked to substantial eco-phenotypic plasticity (see e.g., [ 25, 26]).
In accordance with previous studies, AVP infusion was linked to substantial vasoconstriction, as reflected by a significant increase in SVRI [ 8, 15].
From our comparison of preimplantation development of embryos from outbred XY Sry- and XO females, it was apparent that the greatly impaired fertility of the former is linked to substantial arrest at the 2- to 4-cell stage.
Malnutrition is a serious challenge for the public-health system and "has been linked to a substantial increase in the risk of mortality and morbidity" [ 6].
This reflects wider Western secular trends in which declines in cholesterol, BP, and smoking have been linked to a substantial reduction in CVD mortality.
