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Attending center-based childcare has been linked to shorter nighttime sleep in children.
Besides TP53 aberrations, several of these newly mutated genes have consistently been linked to shorter time to progression/treatment and poor overall survival (e.g. NOTCH1, SF3B1, BIRC3).
Low expression of BAX protein in stage 3 colorectal cancers has been linked to shorter RFS and 5-FU-based treatment resistance [ 26].
Expression of EGFR in resected gastric cancer has been linked to shorter overall survival, more advanced tumor stage, and lymph node metastases in some studies, but not in others [ 5- 9, 12, 13].
Promoter methylation of CDH1 [68] and ITGA4 [29] have been linked to tumor recurrence, and methylation of other genes including adenomatous poly-posis coli (APC) [69], N-methyl D-aspartate 2B (NMDAR2B) [70], tachykinin 1 (TIMP) [65] TImetallopeptidasease inhibitor 3 (TIMP3) [71], UCHL1 [24], and uroplakin 1A (UPK1A) [72] have been linked to shorter survival.
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Good thing, as hearing loss has also been linked to short-term memory loss, fatigue, anxiety, depression, even lower income — on average, up to $12,000 a year less than for their counterparts who use hearing aids, Dr. Kochkin said.
Since these existing helmet systems have not been linked to short- or long-term issues, these measures provide a preliminary, conservative definition of a safe design envelope for evaluating for future developments.
Age-related conditions from osteoarthritis, diabetes and obesity to heart disease, Alzheimer's and stroke have all been linked to short telomeres.
Seizure-induced neurodegeneration in the medial thalamus has been linked to short- and long-term consequences, such as chronic SRS [28].
Low socioeconomic status has been linked to short sleep duration (Stamatakis et al. 2007) and poor sleep quality (Patel et al. 2010).
An important prerequisite for performing such predictions is to establish a model that is able to describe the dose dependency of the signaling pathway 12. Similarly, in a human cancer cell line treated with the pro-apoptotic cytokine TNF-α in combination with the pro-survival factors EGF or insulin, apoptotic responses have been linked to short-term signaling.
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Justyna Jupowicz-Kozak
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