In fact, Bdf1 has been linked to repression of SAGA-dependent genes [32], [39], [40], [41].
Finally, the lambdoid phage transcriptional regulator CII has been linked to repression of the type III secretion system in EHEC (25), the expression of which is necessary for colonization of the mammalian gut (26).
The monomethylations of H3K9 and H4K20 are linked to gene activation, whereas trimethylations of these histones at lysine residues are linked to repression [ 27].
Therefore, we hypothesise that intron retention is not primarily a means of generating novel proteins, but is linked to repression of translation.
The influence of TCPOBOP on formation of HDL was shown by another study, where CAR-dependent decrease in HDL was linked to repression of ApoA-I synthesis [ 19].
Reviewer 2 was surprised that genes silenced by Hairy lacked certain canonical chromatin changes previously suggested to be linked to repression, namely, loss of H3K36me3 and gain of H3K9me3.
This is in keeping with our observations in the HL60 differentiation model system that engagement of the somatic differentiation programme in tumour cells is coupled to G1 arrest and cell-cycle withdrawal into the out-of-cycle state, a process that is linked to repression of the DNA replication licensing machinery (Barkley et al, 2007).
As for the mechanism that governs disassembly of nucleoli in prophase, it may be assumed that it is linked to repression of rDNA transcription, most probably caused by CDK1-cyclin B-directed phosphorylation of components of the rDNA transcription machinery (Heix et al. 1998; Sirri et al. 1999).
A study in Arabidopsis indicated that petal homeotic genes APETALA3 and PISTILLATA downregulate BANQUO genes, which are involved in accumulation of chlorophyll, suggesting that the breakdown of chloroplasts in petal development is linked to repression of genes involved in chlorophyll biosynthesis by nuclear-encoded petal identity genes (Mara et al., 2010).
Some of the differentially expressed miRNA have further been linked to the repression of tumor suppressor genes or the upregulation of oncogenes at the protein product level [20], [21], [22], [23].
Since biofilms have a complex time- and temperature-dependent formation process [20], we analyzed biofilm formation of the hha deletion mutant as a function of time, both in LB and LB glucose (LB glu), since Hha has been linked to catabolite repression [21].
