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Ppargc1a is a multifunctional regulator of metabolism and mitochondrial biogenesis, and has been linked to regulation of glucose homeostasis, CR and a possible role in aging through a physical interaction with Sirt1 in liver [40].
Gata3 has been linked to regulation of cell proliferation and survival [24] and p27kip1 (cdkn1b) is an important regulator of the cell cycle in cochlear sensory epithelial cells [45], [46] and sensory neurons [47].
RUVBL1 has previously been linked to regulation of cilia-associated signaling pathways.
Both miRNAs have also been linked to regulation of the immune response as demonstrated by genetic deletion and transgenic approaches.
Sds22, a regulatory subunit of protein phosphatase 1 (PP1), has recently been linked to regulation of cell shape and apical-basal polarity in Drosophila imaginal disc and follicular epithelia, where a GFP-tagged form of Sds22 localized to the cytoplasm and nucleus [76].
FOXO1 in osteoblasts has also been linked to regulation of serum glucose levels.
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We established that nuclear FAK is associated with chromatin and interacts with a number of TFs and transcriptional regulators, including components of the TFIID complex, that are linked to regulation of Ccl5 expression.
But this time the markets are fairly calm.The current problem seems instead to be linked to regulation.
This regulation occurred during LPS-induced metabolic reprogramming and hereby suggests that metabolic reprogramming is linked to regulation of antiviral cytosolic DNA sensing.
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P et al. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
However, as C-terminal truncations are active in vitro, the essential nature of the C-terminal domain is thought to be linked to regulation [5].
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