In several studies Diamond has shown that performance on the object retrieval task is linked to maturation of the dorsolateral prefrontal cortex (e.g., Diamond and Goldman-Rakic 1986; Diamond 1991a, b).
Thra has been linked to development and maturation of GABAergic cells in the neocortex of mice [46] and could therefore also be part of the development and maturation of the dCINs, a subpopulation of which are know to contain GABA [43].
Maternal depression, which is characterized by withdrawal and lack of engagement, has also been linked to early maturation for female children (Ellis and Garber 2000).
Importantly, the JH/Vg regulatory pathway interacts with worker nutritional status and the insulin signaling pathway, which has also been linked to behavioral maturation [ 49– 51].
miRNA 132 has been linked to the maturation and functional integration of newly generated hippocampal neurons and – in this context – is potentially regulated by hippocampal network activity and CREB-signalling [ 2].
Since HSC expansion in AGM explant cultures has been linked to increased maturation from pre-HSCs rather than HSC proliferation (Taoudi et al., 2008), and since we saw a decrease in intra-aortic clusters and hemogenic endothelial cell numbers in the absence of catecholamines, the latter possibility is more likely.
MiR-134, for example, is localised to the synapto-dendritic compartment of rat hippocampal neurones and has been linked to synaptic development, maturation and plasticity [ 23].
Exploratory behaviour has been linked to both the maturation and activation of reward related circuitry.
A frontally prominent lP3a has been linked to the neural maturation of the frontal cortex and attention control [ 28, 34].
Exposure to ethanol in utero has been linked to delayed sexual maturation in female rats 24 25 and, recently, prenatally exposed male rats also showed delayed reproductive development and onset of spermatogenesis compared with the unexposed rats.
