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Importantly, these extracellular matrix components have been linked to lymphocyte adhesion and migration and to islet inflammation [ 32, 69 ].
In contrast, arginase-induced arginine depletion has been linked to lymphocyte T hyporesponsiveness and reduced expression of the T-cell receptor CD3 ζ chain in immune responses against infections, such as Leishmania, and in reduced tumour immunosurveillance.
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No other PDGF family member could be linked to lymphocyte specific gene expression in our collection of PTCs biopsies.
Whereas the association with survival was the primary focus of our previous study, the current study was designed to discover genes and pathways that might be linked to lymphocyte recruitment.
We observed that the hazardous subset of PC-1 showed significant overlap with numerous hypoxia signatures, and the protective subset was linked to lymphocyte and antigen presentation signatures (Supplementary Table S1).
This multicollinearity comes not as a surprise as pain-related behaviour was linked to lymphocytes and neutrophil counts in psychological intervention on depressive symptoms in cancer patients.
Additional components of innate immune cells such as γδ T-lymphocytes have been linked to diabetes.
Moreover, EBV positivity has been linked to the presence of latently infected lymphocytes in the tumours (Horiuchi et al, 1994; Brink et al, 2000) thus, questioning the role of EBV in BC (Chu et al, 2001).
Decreased or absent ζ chain expression in T lymphocytes and elevated percentages of Fas+CD3+ lymphocytes in the peripheral circulation of patients with solid tumours have been linked to the increased susceptibility of their T lymphocytes to 'spontaneous' apoptosis (Kuss et al, 1999; Chen et al, 2000; Dworacki et al, 2001; Hoffmann et al, 2002).
Aberrant expression or mutation of many of the lineage-specific TFs involved in B lymphocyte development have been linked to the outcome of hematopoietic malignancies.
Finally, the LEF family of TFs, which are highly expressed in pre-B and T lymphocytes [73], have been linked to the regulation and expression of a number of lymphoid-specific genes [74] [79].
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