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Although PM10 has been linked to inflammatory markers in a nationally representative sample (NHANES) using data from earlier cycles (1989 1994); no study has considered these relationships for PM2.5 in more recent time periods.
Due to its role in generating the activated form of NF-κB, an anti-apoptotic and pro-inflammatory regulator of cytokine expression, proteasomal activity has been linked to inflammatory and autoimmune diseases.
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease.
11, 33 ATF6 has also been linked to inflammatory signaling.
Dysregulation of the miR-146 family has often been linked to inflammatory diseases and malignancies.
This phylum has been linked to inflammatory conditions of the mouth such as periodontitis 46.
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Recently, NLRP3 inflammasome activation was linked to inflammatory bone loss and synovial inflammation in IL-10-deficient mice [23].
Due to the overexpression in activated microglia, TSPO is linked to inflammatory responses that occur after brain injury or neurodegenerative diseases.
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
Moreover, the NLR family has gained increased attention, since polymorphisms in certain NLR genes are linked to inflammatory disorders such as Blau syndrome, Crohn's disease or early-onset sarcoidosis [6].
Together, these observations suggest that chronic β-AR stimulation may be linked to inflammatory bladder diseases like IC.
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