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Many factors have been linked to inappropriate antibiotic use, 10– 12 including insufficient knowledge, patient pressure and the pharmaceutical industry.
Neutrophils may damage normal tissue, and a number of clinical conditions such as acute respiratory distress syndrome, septicemia with multiorgan failure, ischemia reperfusion injury and rheumatoid arthritis have all been linked to inappropriate neutrophil-mediated tissue damage.
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Low job satisfaction was linked to inappropriate deployment, low salaries, inadequate support supervision, excessive workload, and poor job security [ 26].
The high risk of stunting observed beyond the 0-23 months-period may be linked to inappropriate food supplementation during the weaning period [ 20].
Moreover, Wnt signaling has already been linked to the inappropriate regulation of the PU.1 transcription factor associated with T-cell lymphoma in mice [ 21].
The right inferior frontal cortex in particular has been linked to the inhibition of inappropriate responses [ 35].
The high antibiotic resistance observed in ICU patients who develop infections limits treatment options and justifies using regimens combining several broad-spectrum antibiotics, even when the presumed infection probability is low, because initial inappropriate therapy has been linked to poor prognoses.
Notably, inappropriate antibiotic choices have been linked to delayed clinical resolution, longer hospital stay, and an increased risk of mortality [ 5, 6].
Whereas lack of eEF1A2 gives rise to the wasted mouse phenotype (Chambers et al, 1998), which involves motor neuron degeneration (Newbery et al, 2005), inappropriate overexpression has now been linked to cancer.
"Inappropriate" activation of NFKB has been linked to AIDS, whereas inhibition has been linked to disorders in immune cell development.
Inappropriate hospital admission for patients with palliative care needs has been linked to family carers being unable to cope and lack of community services.
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