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Functional hypothalamic amenorrhea is characterized by anovulation caused by reduced gonadotropin-releasing hormone drive and is associated with hypercortisolemia that has been linked to heightened hypothalamic-pituitary-adrenal reactivity to common psychological and metabolic challenges.
Regarding clinical outcomes, levels of neuroticism and agreeableness have been linked to heightened symptom levels [ 18, 19].
Waist circumference has been shown to be an independent risk factor for cardiovascular problems such as high blood pressure, and visceral fat deposits have been linked to heightened insulin resistance (12).
In addition to being a source of distress, various forms of sleep disturbance have also been linked to heightened levels of thought disorder [ 7] and symptoms of excitement [ 8] and may portend relapse [ 9].
In all of these cases there is some form of affective regulation that has been linked to heightened response as they either strengthen the impact of the positive stimuli or reduce the negative ones [ 63].
These researchers, who include Richard S. Pond of the University of Kentucky, note that narcissism has been linked to heightened anger and problems maintaining relationships.
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Pain catastrophizing is linked to heightened pain and poorer coping among individuals with chronic pain, yet little is known about how pain catastrophizing associates with sleep and pain over the course of treatment for chronic pain.
Similarly, at Réunion island (where the baseline GDM rate has reached 7% for a couple of years [43]), pdm influenza (H1N1/09)v was linked to heightened GDM rate like recently observed in Victoria, Australia [20].
Stress places a metabolic burden on homeostasis and is linked to heightened sympathetic activity, increased energy expenditure and pathology.
Efforts to address food security during periods of drought should be linked to heightened food safety efforts to prevent consuming aflatoxin-contaminated food.
Catastrophizing was linked to heightened emotional distress and disability, as well as a more intense pain experience, and more pronounced displays of pain behavior [ 7, 32- 34].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com